Omeprazole is a kind of medicine known as a proton pump inhibitor (PPI). Proton pumps are found in the lining of the stomach and make acid which digests food. Omeprazole prevents these proton pumps from working properly, which reduces the amount of acid the stomach makes. This reduces the risk of acid reflux and indigestion.

How long does it take for omeprazole to work?

Most people who get regular acid reflux start to feel better within 2-3 days of first taking omeprazole. This will differ from person to person, and it may take up to 4 weeks before all your symptoms disappear. If you take omeprazole for two weeks and notice no difference to your symptoms, book an appointment to see your GP. They may suggest an alternative medicine to take.

How effective is omeprazole?

Omeprazole is an effective medicine used to reduce acid levels in the stomach, and is often relied on to treat acid reflux, indigestion, and other stomach problems.

Swallow omeprazole tablets whole with a glass of water, with or without food. It’s usual to take omeprazole once a day, but for severe illness some people take it twice a day – once in the morning and once at night.

When should I take omeprazole?

Usually, omeprazole is taken once a day, first thing in the morning. It doesn’t upset the stomach, so it can be taken with or without food.

How long do I use omeprazole for?

Omeprazole tablets should only be taken for up to four weeks. Any longer, and you are at risk of having serious side effects.

How many omeprazole can I take?

You can take up to two omeprazole tablets a day, but this will depend on the dose you have been prescribed. If you have mild indigestion, you will likely only take 20mg a day.

Can I buy omeprazole online?

Yes, you can order omeprazole online through Superdrug Online Doctor. You will need to complete a brief questionnaire, which will be reviewed by one of our doctors to ensure omeprazole is appropriate for you. If approved, your medication will be sent directly to you or to your local Superdrug Pharmacy for pickup.

Can I buy omeprazole over the counter?

Yes, omeprazole can be sold without a prescription at pharmacies. You can order it online through Superdrug Online Doctor, and if our doctors confirm it’s suitable for you, it will be delivered directly to your address or made available for pickup at your local Superdrug store.

Can I get omeprazole on the NHS?

Yes, omeprazole can be prescribed on the NHS by your doctor if it is deemed necessary for your treatment.

Omeprazole is a commonly prescribed medication, and most people do not experience any side effects. However, as with any medication, some individuals may experience adverse reactions, especially when taking high doses or using it for an extended period.

Common Side Effects:

• Dizziness and sleepiness
• Headaches
• Stomach pain
• Constipation
• Flatulence
• Nausea

Uncommon Side Effects:

• Loss of appetite
• Hair loss
• Stomach inflammation
• Changes in taste

Rare Side Effects:

• Liver damage
• Pancreatitis
• Skin disorders

Can omeprazole cause weight gain?

Long-term use of omeprazole has been associated with weight gain. While the exact reason is unclear, it is thought that relief from acid reflux and indigestion may lead to increased food consumption.

Can omeprazole cause constipation?

Yes, constipation is a possible side effect of omeprazole for some individuals.

What to do if you experience side effects:

Most side effects are temporary and may resolve once you stop taking omeprazole. If you experience serious side effects or if common side effects persist even after stopping the medication, consult your GP for advice.

Side Effects of Long-Term Use:

Taking omeprazole for extended periods increases the risk of serious side effects. Prolonged use (over three months) may lead to a decrease in magnesium levels in your blood. Long-term use (over a year) can also increase the risk of:

• Bone fractures
• Gut infections
• Vitamin B12 deficiency

Omeprazole may not be right for everyone. Certain conditions or medications can interact with omeprazole, making it less effective or potentially unsafe.

Omeprazole is known to interact with:

• heart medicines like digoxin

• antifungal medicines like itraconazole and voriconazole

• methotrexate

• HIV medicines

• anti-epilepsy medicines like phenytoin

• antibiotics like rifampicin

• blood thinning medicines like clopidogrel and warfarin

Tell your doctor about any medication you are taking before starting your treatment with omeprazole.

Alternative Acid Reflux Medicines:

• Lansoprazole
• Esomeprazole
• Pantoprazole

Natural Alternatives to Omeprazole:

If you want to manage acid reflux without medication, certain lifestyle and dietary changes may help alleviate symptoms:

• Maintain a healthy weight
• Avoid foods that trigger symptoms (e.g., spicy and fatty foods)
• Limit caffeinated drinks (e.g., tea and coffee)
• Quit smoking
• Avoid eating at least 3 hours before going to bed

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